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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTNNB1
All Species:
48.79
Human Site:
S246
Identified Species:
82.56
UniProt:
P35222
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35222
NP_001091679.1
781
85497
S246
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Chimpanzee
Pan troglodytes
XP_001137676
774
84747
S239
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Rhesus Macaque
Macaca mulatta
XP_001115474
511
55731
L67
T
Y
T
Y
E
K
L
L
W
T
T
S
R
V
L
Dog
Lupus familis
XP_850439
744
81740
S236
A
L
V
R
M
L
S
S
P
V
E
S
V
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q02248
781
85452
S246
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Rat
Rattus norvegicus
Q9WU82
781
85436
S246
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516985
781
85506
S246
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Chicken
Gallus gallus
NP_990412
781
85420
S246
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Frog
Xenopus laevis
P26233
781
85431
S246
A
L
V
K
M
L
G
S
P
V
D
S
V
L
F
Zebra Danio
Brachydanio rerio
NP_571134
780
85502
S245
A
L
V
K
V
L
G
S
P
V
D
S
V
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18824
843
91134
S254
A
L
V
K
L
L
S
S
P
V
E
S
V
L
F
Honey Bee
Apis mellifera
XP_391947
811
88602
S255
A
L
V
K
L
L
S
S
P
M
E
S
V
L
F
Nematode Worm
Caenorhab. elegans
O44326
678
74493
I234
D
G
L
Y
F
L
L
I
D
D
A
P
S
K
I
Sea Urchin
Strong. purpuratus
NP_001027543
825
89711
S267
A
L
I
K
L
L
S
S
P
V
E
S
V
L
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
65.4
66.4
N.A.
99.8
99.7
N.A.
99.7
99.3
97.4
97.1
N.A.
65.7
67.6
28.5
67.2
Protein Similarity:
100
99
65.4
77.4
N.A.
99.8
99.7
N.A.
99.8
99.6
99
98.9
N.A.
77.2
80.1
46.4
77.7
P-Site Identity:
100
100
6.6
80
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
80
73.3
6.6
73.3
P-Site Similarity:
100
100
13.3
93.3
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
13.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
86
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
8
8
58
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
29
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
86
% F
% Gly:
0
8
0
0
0
0
58
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
79
0
8
0
0
0
0
0
0
0
8
0
% K
% Leu:
0
86
8
0
22
93
15
8
0
0
0
0
0
86
8
% L
% Met:
0
0
0
0
58
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
86
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
29
86
0
0
0
93
8
0
0
% S
% Thr:
8
0
8
0
0
0
0
0
0
8
8
0
0
0
0
% T
% Val:
0
0
79
0
8
0
0
0
0
79
0
0
86
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
8
0
15
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _